The Role of Chemokines in the Pathogenesis of HTLV-1

R Zargari, M Mahdifar, A Mohammadi… - Frontiers in …, 2020 - frontiersin.org
HAM/TSP and ATL in a small proportion of HTLV-1 carriers, … chemokine is CCR6, which is
also increased in HTLV-1 infected … The levels of CXCR2 and its ligands are elevated in various …

HTLV1 oncovirus‐host interactions: From entry to the manifestation of associated diseases

S Ahmadi Ghezeldasht, SAA Shamsian… - Reviews in medical …, 2021 - Wiley Online Library
HAM/TSP in allograft recipients from HTLV-1 healthy carriers … + CXCR2-expressing T cells
in HAM/TSP patients was higher … expression of CXCR3 and higher expression of CCR6 were …

Gene expression study of host-human T-cell leukaemia virus type 1 (HTLV-1) interactions: adult T-cell leukaemia/lymphoma (ATLL)

M Rahimzada, M Nahavandi, M Saffari… - Molecular Biology …, 2023 - Springer
… such as multiple sclerosis, HAM/TSP, glioma, Alzheimer and … of CXCR3 and CCR6 chemokine
receptors gene expression … progression to cancer through its ligand, unlike other studies …

Th17/IL-17 Axis in HTLV-1-associated myelopathy tropical spastic Paraparesis and multiple sclerosis: novel insights into the immunity during HAMTSP

M Shafiei, SH Mozhgani - Molecular Neurobiology, 2023 - Springer
… role of Th17 cells during HAM/TSP. Furthermore, for better … patients with HAM/TSP was
17-fold higher than the HTLV-1-… double positive Th17s or CD4+CCR6+CXCR3+CCR4+ that are …

Molecular insight into the study of adult T-cell leukemia/lymphoma (ATLL): Ten-year studies on HTLV-1 associated diseases in an endemic region

F Ashrafi, M Rahimzada, M Parandi, A Mirhosseini… - Gene, 2022 - Elsevier
… studies, CCR6 and VEGFA were highly expressed in the … in the ATLL patients but up-regulated
in the patients with HAM/TSP. … On the other hand, CXC chemokines and their ligands play …

CCR4 as a therapeutic target for cancer immunotherapy

O Yoshie - Cancers, 2021 - mdpi.com
… review entitled “CCR4 and its ligands: from bench to bedside… Th17 cells have been shown
to express CCR6 and CCR4 [46… ATLL, HAM/TSP tends to develop in HTLV-1 carriers infected …

[HTML][HTML] MiR-150 in HTLV-1 infection and T-cell transformation

DM D'Agostino, V Raimondi, M Silic-Benussi… - Frontiers in …, 2022 - frontiersin.org
… of PBMC from asymptomatic HTLV-1-infected patients (ASP) … its altered expression in a variety
of neoplasms (29, 30), the … express high levels of both CCR6 and its ligand, CCL20, which …

[HTML][HTML] High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseases

F Mozayeni, SA Rezaee, FJ Azad… - Iranian Journal of …, 2020 - ncbi.nlm.nih.gov
… Healthy carrier was attributed to patients with positive HTLV-1 … (30) found that HTLV-1
provirus load in Iranian HAM/TSP patients is one of the major risk factors for developing HAM/TSP. …

Biomarkers in a Cohort of HIV-Infected Patients Single-or Co-Infected with HTLV-1, HTLV-2, and/or HCV: A Cross-Sectional, Observational Study

A Caterino-de-Araujo, KR Campos, LMS Oliveira… - Viruses, 2022 - mdpi.com
HTLV-1-infected individuals with HAM/TSP or dermatological diseases compared to
asymptomatic carriers … could be done since no case of HAM/TSP was detected, and the highest …

Viral-induced neuroinflammation: Different mechanisms converging to similar exacerbated glial responses

B Rocamonde, U Hasan, C Mathieu… - Frontiers in …, 2023 - frontiersin.org
… , the HTLV-1 footprint is absent in the brain of patients with … Unlike HAM/TSP, here,
HTLV-1-driven encephalitis develops … HTLV-1 carriers although to a lesser degree than that of …